Study on cerebral perfusion and cerebral functional connectivity in patients with neuromyelitis optica spectrum disorder
10.3969/j.issn.1002-1671.2024.08.002
- VernacularTitle:视神经脊髓炎谱系疾病患者脑灌注和脑功能连接的研究
- Author:
Juan CHEN
1
;
Ting YOU
;
Chuan YUAN
;
Tingting YUAN
;
Xin SHI
;
Hui DAI
Author Information
1. 遵义医科大学附属医院放射科,贵州 遵义 563000
- Keywords:
magnetic resonance imaging;
neuromyelitis optica spectrum disorder;
functional connectivity;
arterial spin labeling
- From:
Journal of Practical Radiology
2024;40(8):1224-1227
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in cerebral blood flow(CBF)and whole-brain functional connectivity(FC)in patients with neuromyelitis optica spectrum disorder(NMOSD)examined by conventional MRI.Methods Twenty-two patients with NMOSD and 25 matched healthy controls(HC)were included,and all subjects'conventional MRI sequences,arterial spin labeling(ASL),and resting-state functional magnetic resonance imaging(rs-fMRI)image data were acquired,and the brain regions with CBF differences between groups extracted based on ASL were used as seed points for whole-brain FC analysis,the FC differences between the groups were compared,and the correlation between the parameter values and the expanded disability status scale(EDSS)scores were analyzed.Results NMOSD patients exhibited a decrease in CBF value in the right supratemporal gyrus,bilateral calcarine fissure and right supplementary motor area,while the right middle temporal gyrus displayed an increase when compared to HC.Whole-brain FC analysis based on seed points revealed an increase in FC value between bilateral calcarine fissure and olfactory cortex,as well as between right supplementary motor area and left superior frontal gyrus.While FC value between the right supplementary motor area and left precentral gyrus,bilateral thalamus,right supraoccipital gyrus were decreased.The FC value between the right supratemporal gyrus and right inferior parietal lobule,left supratemporal gyrus,right precuneus lobes showed a decrease[Gaussian random field(GRF)-corrected,P＜0.05].There was a correlation between CBF values of bilateral calcarine fissure and EDSS scores in NMOSD patients(rs=-0.456,P=0.033).Conclusion There are CBF and FC abnormalities in multiple brain regions in NMOSD patients,which provide imaging basis and insights for the brain micropathological changes of NMOSD,and help to understand the pathology and neural mechanism of NMOSD.
