Potential value of L-citrulline in the treatment of persistent pulmonary hypertension of the newborn
10.3760/cma.j.cn101070-20240124-00053
- VernacularTitle:L-瓜氨酸治疗新生儿持续性肺动脉高压的潜在价值
- Author:
Xingyue YANG
1
;
Junjuan ZHONG
;
Fang XU
;
Xiuzhen YE
Author Information
1. 国家临床重点专科建设项目单位/广东省妇幼保健院新生儿科，广东省新生儿重症医学专业质量控制中心，广州 511400
- Keywords:
Infant, newborn;
Persistent pulmonary hypertension;
L-citrulline;
Treatment
- From:
Chinese Journal of Applied Clinical Pediatrics
2024;39(12):943-946
- CountryChina
- Language:Chinese
-
Abstract:
Persistent pulmonary hypertension of the newborn (PPHN) is a common and critical disease in the neonatus characterized by persistent pulmonary hypertension and hypoxemia, with a high mortality.Except for intubation and ventilator support, recognized treatments often require the application of pulmonary vasodilators drugs, such as inhaled nitric oxide, Sildenafil, etc, each with its own advantages.In recent years, L-citrulline, as a potential therapeutic option, has shown huge potential in PPHN treatment.The purpose of this review is to explore the possible potential of L-citrulline in the treatment of PPHN in terms of therapeutic mechanism, pharmacokinetics, current status of research and future perspectives.
