Research progress on ferroptosis in sepsis-induced liver injury
10.3760/cma.j.cn101070-20231227-00453
- VernacularTitle:铁死亡在脓毒症肝损伤中的研究进展
- Author:
Chengzhu XU
1
;
Danqun JIN
;
Chao DAI
;
Yuanyuan XU
Author Information
1. 安徽医科大学儿童医学中心，安徽省儿童医院重症医学科，合肥 230051
- Keywords:
Ferroptosis;
Sepsis;
Liver injury
- From:
Chinese Journal of Applied Clinical Pediatrics
2024;39(11):877-880
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, as researchers delve deeply into the cell death mechanisms, ferroptosis, as a new iron-dependent cell death mode, has gradually become a research hotspot.It is mainly triggered by iron overload and lipid peroxidation in organisms.Sepsis-induced liver injury is an important pathophysiological process in the systemic inflammatory response caused by infection, which is closely related to various cell death modes.This review aims to explore the research progress on ferroptosis in sepsis-induced liver injury, including the mechanism of ferroptosis occurrence in sepsis-induced liver injury, its relationship with sepsis-induced liver injury, and possible therapeutic strategies for ferroptosis.
