Clinical characteristics and vaccination status of SARS-CoV-2 Omicron variant infected children
10.3760/cma.j.cn112140-20220506-00417
- VernacularTitle:新型冠状病毒Omicron变异株感染患儿的临床特征及免疫效应分析
- Author:
Xuelin WANG
1
;
Jia ZHAI
;
Yingxue ZOU
Author Information
1. 天津市儿童医院（天津大学儿童医院）马场院区感染科，天津 300074
- Keywords:
Child;
SARS-CoV-2;
Omicron variant;
Clinical characteristics;
SARS-CoV-2 antibody
- From:
Chinese Journal of Pediatrics
2022;60(7):671-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics and vaccination status of SARS-CoV-2 Omicron variant infected children.Methods:A total of 105 children infected with Omicron variant admitted to Tianjin Haihe Hospital (designated referral hospital for SARS-CoV-2 infection in Tianjin) from January 8, 2022 to February 3 were included for a retrospective study. The cases were divided into pneumonia group and non-pneumonia group according to chest imaging. Based on the doses of inactivated SARS-CoV-2 vaccine, the children who completed SARS-CoV-2 antibody test within 3 days after hospitalization were divided into 2-dose group and <2-dose group.Rank sum test and Chi-square test were used for the comparison between the groups.Results:The age of these 105 children was 10.0 (8.0, 11.0) years on admission, 53 children were males and 52 were females. Eighty-seven cases (82.9%) had mild symptoms, 13 cases (12.4%) had common symptoms and 5 cases (4.8%) were asymptomatic. Ninety-one cases (86.7%) completed 2 doses vaccination. The clinical symptoms were characterized by cough (74 cases, 70.5%), fever (58 cases, 55.2%), sore or dry throat (34 cases, 32.4%), nasal congestion (28 cases, 26.7%), rhinorrhea (23 cases, 21.9%). None of the children received antivirals, steroids, immunosuppressant or oxygen therapy. Seventy-six cases (72.4%) received traditional Chinese medicine treatment. The pneumonia group had a higher rate of positive SARS-CoV-2 IgG within 1 day after admission (13/13 vs. 87.0% (80/92), χ 2=42.81, P<0.001) than the non-pneumonia group. Among the 62 children who had serial SARS-CoV-2 antibody tests within 3 days after hospitalization, Compared to the <2-dose group, the 2-dose group had a higher rate of nucleic acid conversion within 16 days after onset and a higher rate of positive SARS-CoV-2 IgG 1 day after admission and 3 days after hospitalization (96.4% (54/56) vs. 4/6, 100.0% (56/56) vs. 2/6, 100.0% (56/56) vs. 3/6, all P<0.05). Conclusions:Most children infected with Omicron variant have mild symptoms, mainly respiratory infection symptoms. The proportion of SARS-CoV-2 antibody IgG positive in children who have received 2 doses of inactivated SARS-CoV-2 vaccines is higher,and the time of whose nucleic acid conversion may be shortened.
