Study on the role of genetic counseling and follow-up mode of medical cooperation in the health management of carriers of genetic gynecological tumor variants
10.3969/j.issn.1672-8467.2024.06.013
- VernacularTitle:医护合作的遗传咨询和随访模式在遗传性妇科肿瘤变异基因携带者健康管理中的作用研究
- Author:
Hui WANG
1
;
Fang-Qin FAN
;
Xia WANG
;
Yu KANG
Author Information
1. 复旦大学附属妇产科医院1期临床试验病房 上海 200011
- Keywords:
gynecological tumors;
genetic;
medical and nursing cooperation;
carriers of mutated genes;
health management
- From:
Fudan University Journal of Medical Sciences
2024;51(6):970-976
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a genetic counseling and follow-up model for hereditary gynecologic tumor variant gene carriers in medical and nursing cooperation,and to evaluate its practical effect.Methods A total of 70 hereditary gynecologic tumor carriers who were admitted to the Gynecologic Cancer Genetic Counseling Clinic,Obstetrics and Gynecology Hospital,Fudan University from Jan 2021 to Jun 2023 were randomly divided into control group and observation group,with 35 cases in each group.The control group underwent routine outpatient management of tumor genetic counseling,and the observation group underwent the genetic counseling and follow-up mode of medical and nursing cooperation.Before and 6 months after intervention,the degree of psychological anxiety-depression,psychological crisis,quality of life and related clinical indicators of the two groups of mutant gene carriers were evaluated.Results In terms of the degree of psychological anxiety and depression,the observation group was significantly lower than the control group after 6 months of intervention(P<0.05).In terms of psychological crisis,the scores of all dimensions in the observation group were lower than those in the control group after 6 months of intervention(P<0.05).In terms of quality of life.After 6 months of intervention,the scores of the observation group in all seven dimensions were higher than those in the control group(P<0.05).After 6 months of intervention,8 patients in the observation group underwent prophylactic salpingo-oophorectomy,4 patients in the childbearing age carrier successfully underwent preimplantation genetic testing,and the number of cases in the control group was 0.Conclusion The genetic counseling and follow-up mode of hereditary gynecologic tumor variant gene carriers can provide a full-cycle,standardized and intelligent management for mutant gene carriers,reduce the degree of psychological anxiety-depression,psychological crisis,improve their quality of life,and guide them to adopt scientific methods to prevent the occurrence of hereditary tumors,which provides a practical basis for the management of hereditary gynecologic tumor variant gene carriers.
