Ropivacaine dosage study for sub-high altitude cesarean spinal anesthesia
10.3969/j.issn.1672-8467.2024.05.019
- VernacularTitle:罗哌卡因用于亚高原地区脊麻剖宫产的剂量研究
- Author:
Le ZHANG
1
;
Meng-Zhao MA
;
Wang-Jun DONG
;
Yao-Jun LU
;
Ye-Yue GAO
;
Shao-Qiang HUANG
;
Chen YANG
Author Information
1. 复旦大学附属妇产科医院麻醉科 上海 200090
- Keywords:
sub-high altitude;
ropivacaine;
cesarean section;
median effective dose(ED50);
spinal anesthesia
- From:
Fudan University Journal of Medical Sciences
2024;51(5):778-783
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the median effective dose(ED50)of ropivacaine for spinal anesthesia in sub-high altitude cesarean sections.Methods A total of 30 parturients from sub-high altitudes received initial 14 mg(1.4 mL)of 1%ropivacaine intrathecally.Effectiveness was defined by sensory block to T6 within 15 minutes without additional epidural anesthesia.Doses were adjusted by±1 mg based on response.ED50 and 95%CI were estimated using Dixon's method and isotonic regression.Adverse reactions were noted.Results Thirty parturients with an average age of(30.88±5.56)years,gestational weeks of(40±1.41)weeks,height of(156.69±5.80)cm,and weight of(67.44±10.48)kg were studied.The ED50 was 10.68 mg(95%CI:9.65-12.58 mg)by Dixon's method and 10.33 mg(95%CI:9.41-12.07 mg)by isotonic regression.Intraoperatively,8 cases of hypotension,1 case of bradycardia,and 7 cases of nausea and vomiting were observed,no hypertension or shivering occurred among the parturients.Conclusion The ED50 for ropivacaine in sub-high altitude cesarean sections is 10.68 mg,which is higher than the currently known ED50 required for patients in plain areas.
