Value of lung ultrasound score for evaluation of blast lung injury in goats
10.1016/j.cjtee.2019.11.005
- VernacularTitle:Value of lung ultrasound score for evaluation of blast lung injury in goats
- Author:
Yu-Qi XUE
1
;
Chun-Shuang WU
;
Hua-Cai ZHANG
;
Juan DU
;
Jian-Hui SUN
;
An-Qiang ZHANG
;
Ling ZENG
;
Mao ZHANG
;
Jian-Xin JIANG
Author Information
1. State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing 400042, China
- Keywords:
Blast injuries;
Lung injury;
Goats;
Bio-shock tube
- From:
Chinese Journal of Traumatology
2020;23(1):38-44
- CountryChina
- Language:Chinese
-
Abstract:
Purpose::To establish a severe blast lung injury model of goats and investigate the feasibility of lung ultrasonic score in the evaluation of blast lung injury.Methods::Twenty female healthy goats were randomly divided into three groups by different driving pressures: 4.0 MPa group ( n = 4), 4.5 MPa group ( n = 12) and 5.0 MPa group ( n = 4). The severe blast lung injury model of goats was established using a BST-I bio-shock tube. Vital signs (respiration, heart rate and blood pressure), lung ultrasound score (LUS), PO 2/FiO 2 and extravascular lung water (EVLW) were measured before injury (0 h) and at 0.5 h, 3 h, 6 h, 9 h, 12 h after injury. Computed tomography scan was performed before injury (0 h) and at 12 h after injury for dynamic monitoring of blast lung injury and measurement of lung volume. The correlation of LUS with PaO 2/FiO 2, EVLW, and lung injury ratio (lesion volume/total lung volume*100%) was analyzed. All animals were sacrificed at 12 h after injury for gross observation of lung injury and histopathological examination. Statistical analysis was performed by the SPSS 22.0 software. The measurement data were expressed as mean ± standard deviation. The means of two samples were compared using independent-sample t-test. Pearson correlation analysis was conducted. Results::(1) At 12 h after injury, the mortality of goats was 0, 41.67% and 100% in the 4.0 Mpa, 4.5 MPa and 5.0 MPa groups, respectively; the area of pulmonary hemorrhage was 20.00% ± 13.14% in the 4.0 Mpa group and 42.14% ± 15.33% in the 4.5 MPa group. A severe lung shock injury model was established under the driving pressure of 4.5 MPa. (2) The respiratory rate, heart rate, LUS and EVLW were significantly increased, while PaO 2/FiO 2 was significantly reduced immediately after injury, and then they gradually recovered and became stabilized at 3 h after injury. (3) LUS was positively correlated with EVLW (3 h: r = 0.597, 6 h: r = 0.698, 9 h: r = 0.729; p < 0.05) and lung injury ratio (12 h: r= 0.884, p < 0.05), negatively correlated with PaO 2/FiO 2 (3 h: r =－0.871, 6 h: r =－0.637, 9 h: r =－0.658; p < 0.05). Conclusion::We established a severe blast lung injury model of goats using the BST-I bio-shock tube under the driving pressure of 4.5 MPa and confirmed that ultrasound can be used for quick evaluation and dynamic monitoring of blast lung injury.
