Influencing factors and prevention strategies of osteoporosis in elderly women after radical mastectomy
10.3760/cma.j.cn115807-20240608-00195
- VernacularTitle:老年女性乳腺癌根治术后骨质疏松症的影响因素及预防策略
- Author:
Haiyan LI
1
;
Meihong LI
;
Fang CHEN
Author Information
1. 长治医学院附属和济医院心胸外科，长治 037000
- Keywords:
Breast cancer;
Radical mastectomy;
Osteoporosis;
Elderly women
- From:
Chinese Journal of Endocrine Surgery
2024;18(5):670-674
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the incidence of osteoporosis in elderly women after radical mastectomy and analyze its influencing factors, so as to provide guidance for the prevention of this disease.Methods:Clinical data of 103 elderly women treated in our hospital after radical mastectomy from Jan. 2020 to Jan. 2021 were collected and separated into osteoporosis group ( n=58) and non-osteoporosis group ( n=45) according to whether osteoporosis occurred. The factors affecting the occurrence of osteoporosis and the relationship between endocrine hormones and bone metabolism were analyzed, and prevention strategies were formulated. Results:(1) The proportion of patients with osteoporosis >70 years old, menopausal years ≥5 years, body mass index <25kg/m 2, endocrine therapy in osteoporosis group was higher than that in non-osteoporosis group ( χ2 =8.68, 18.54, 9.72, 16.98, 36.51, P=0.003, <0.001, 0.002, <0.001, <0.001) ; (2) The level of estradiol in the osteoporosis group was lower than the other group ( t value =20.53, P<0.05), and the level of follicle-stimulating hormone was higher ( t value=19.14, P<0.05) ; (3) Old age, endocrine therapy, low bone mineral density and low estradiol level were the risk factors for osteoporosis after radical mastectomy ( P<0.05) ; (4) Pearson correlation analysis showed that bone mineral density in patients with osteoporosis after radical mastectomy was positively correlated with estradiol and testosterone levels ( r=0.352, 0.316, P<0.05), and negatively correlated with follicle-stimulating hormone levels ( r=-0.334, P<0.05) . Conclusions:Osteoporosis in elderly women with radical mastectomy is affected by age, endocrine therapy, bone mineral density and estradiol, and there is a correlation between hormone levels and bone mineral density. Clinical prevention and treatment measures should be implemented in the direction of monitoring bone mineral density, physical exercise, safe drug use, and prevention of falling.
