Value of multimodal ultrasound parameters combined with peripheral blood lymphocyte-monocyte ratio in predicting recurrence and metastasis after radical breast cancer surgery
10.3760/cma.j.cn115807-20240423-00131
- VernacularTitle:多模态超声参数联合外周血淋巴细胞与单核细胞比值预测乳腺癌根治术后复发转移的价值
- Author:
Xiaoyuan CHEN
1
;
Jin LI
;
Xiaoxia HOU
Author Information
1. 西北妇女儿童医院医学超声中心，西安 710061
- Keywords:
Breast cancer;
Radical operation;
Multimode ultrasound;
Lymphocyte-monocyte ratio;
Recurrence and metastasis
- From:
Chinese Journal of Endocrine Surgery
2024;18(5):648-651
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of multimodal ultrasound parameters combined with peripheral blood lymphocyte-monocyte ratio (LMR) in predicting recurrence and metastasis after radical breast cancer surgery.Methods:A total of 139 patients with breast cancer admitted to Northwest Women’s and Children’s Hospital from Jan. 2021 to Jan. 2022 were studied. The patients underwent postoperative multimodal ultrasonography and peripheral blood lymphocyte and monocyte examination. Patients were followed up for 2 years after surgery to evaluate postoperative recurrence and metastasis, and analyze the value of multimodal ultrasound parameters combined with LMR in predicting recurrence and metastasis of patients.Results:Among 139 patients, 32 recurrences and metastases occurred during 2-year follow-up; The peak systolic velocity (PSV), resistance index (RI), maximum lesion diameter, elasticity score, area under the curve (AUC) and peak intensity (PI) in patients with recurrent metastasis were higher than those without recurrent metastasis ( t=7.37, 4.75, 4.75, 5.46, 4.24, 5.22, P<0.05), and the LNR in patients with recurrent metastasis was lower. Pearson correlation analysis showed that PSV, RI, maximum lesion diameter, elasticity score, AUC, PI were negatively correlated with LMR ( r=-0.418, -0.502, -0.633, -0.526, -0.448, -0.482). P<0.05) ; The ROC curve showed that the AUC of PSV, RI, maximum lesion diameter, elasticity score, AUC, PI and LMR for predicting recurrence and metastasis were 0.852, 0.784, 0.791, 0.789, 0.615, 0.725 and 0.728, respectively, and the combined AUC value of each index was 0.992. Conclusions:The use of multimodal ultrasound parameters combined with LMR can improve the prediction value of recurrence and metastasis after radical breast cancer surgery.
