Value of TRPS1 in diagnosis and differential diagnosis of synovial sarcoma
10.13315/j.cnki.cjcep.2024.10.011
- VernacularTitle:TRPS1在滑膜肉瘤诊断和鉴别诊断中的价值
- Author:
Yijing LIU
1
;
Xiaojuan WANG
;
Zhiwen LI
;
Lan CHEN
;
Yongfeng ZHANG
;
Wenbin HUANG
Author Information
1. 河南科技大学第一附属医院病理科,洛阳 471003
- Keywords:
synovial sarcoma;
TRPS1;
mimicker;
diagnosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(10):1064-1067,1074
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the expression of of mono-clonal and polyclonal TRPS1 antibodies in synovial sarcoma,and to explore the value of TRPS1 in the diagnosis and differen-tial diagnosis of synovial sarcoma and the sensitivity and speci-ficity of polyclonal TRPS1 for the diagnosis of synovial sarcoma.Methods Immunohistochemical EnVision method was used to detect the expression of monoclonal and polyclonal TRPS1 anti-bodies in the synovial sarcomas and its mimickers.Results A-mong 31 cases of synovial sarcoma,the positive rates of poly-clonal and monoclonal TRPS1 antibodies were 54.8％and 93.5％,respectively.Of 30 synovial sarcoma mimicking le-sions,2 were positive for TRPS1(polyclonal antibody),which was 6.67％,and TRPS1 was more frequently expressed in syno-vial sarcoma than in non-synovial sarcoma(P＜0.05).The sensitivity of polyclonal TRPS1 antibody for the diagnosis of syn-ovial sarcoma was 93.5％,and the specificity was 93.3％.Conclusion Polyclonal TRPS1 antibody has a higher sensitivity and specificity for the diagnosis of synovial sarcoma and it there-fore is recommended in routine pathologic diagnosis.
