Application of melatonin in peripheral nerve injury repair
10.13591/j.cnki.kqyx.2024.08.011
- VernacularTitle:褪黑素在周围神经损伤修复中的应用
- Author:
Lining LIN
1
;
Mouyuan SUN
;
Huiming WANG
Author Information
1. 浙江大学医学院附属口腔医院,浙江大学口腔医学院,浙江省口腔疾病临床医学研究中心,浙江省口腔生物医学研究重点实验室,浙江大学癌症研究院,口腔生物材料与器械浙江省工程研究中心,浙江杭州(310000)
- Keywords:
peripheral nerve injury;
melatonin;
anti-inflammatory;
cell behavior and fate regulation;
mechanism
- From:
STOMATOLOGY
2024;44(8):617-623
- CountryChina
- Language:Chinese
-
Abstract:
The increasing incidence of peripheral nerve injuries brought on by trauma or tumors is substantially interfering with people's lives due to the causal sensory and motor dysfunctions.Peripheral nerves have some self-repair ability after injury,but they are limited by the degree of injury and the body's condition.The postoperative recovery of nerve function in patients is not satisfactory,which is closely related to the local inflammatory microenvironment after injury.Melatonin,a compound naturally synthesized in the pineal gland,protects peripheral nervous system cells from oxidative inflammation after injury and regulates their behavior and fate.Therefore,it has good application prospect in nerve tissue engineering.In this paper,we review the synthesis,metabolic processes un-derlying melatonin,mechanism of action as well as the current status of its application in peripheral nerve regeneration as well as poten-tial application for oral diseases.In this way,it further provides a new idea for the clinical treatment of peripheral nerve injury.
