Effect of light on stability of colchicine and screening of photostabilizers
10.7644/j.issn.1674-9960.2024.05.009
- VernacularTitle:光对秋水仙碱稳定性的影响及光稳定剂筛选
- Author:
Guobao YANG
1
;
Jing DONG
;
Wei GONG
;
Meiyan YANG
;
Chunsheng GAO
;
Yuli WANG
;
Yang YANG
Author Information
1. 军事科学院军事医学研究院,北京 100850
- Keywords:
colchicine;
sustained-release pellets;
photochemical degradation;
photostability;
photostabilizer;
iron oxide
- From:
Military Medical Sciences
2024;48(5):376-381
- CountryChina
- Language:Chinese
-
Abstract:
Objective To enhance the photostability of colchicine(COL)for sustained-release COL pellets.Methods The degradation was investigated by studying the photochemical degradation kinetics of COL.The impact of such physical properties of the photostabilizers as the type,color,dosage,and position on the photostability of COL in sustained-release pellets was also evaluated.Results The contents of photochemical degradation products did not increase after 10 days of light exposure to sustained-release COL pellets with red iron oxide of 4％(w/w)as the protective layer.Conclusion The findings of this study indicate that use of iron oxide as a photostabilizer in sustained-release COL pellets can significantly reduce the photochemical degradation of COL in the pellets.
