Research progress on the role of mesenchymal stem cells in regulating immune response for treatment of traumatic brain injury

VernacularTitle:间充质干细胞调控免疫反应治疗创伤性脑损伤的作用机制研究进展
Author: Yang GAO ¹ ; He-Wei QIN ; Dan-Dan LIU
Author Information

1. 河南中医药大学康复医学院,河南郑州 450046
Keywords: traumatic brain injury; mesenchymal stem cells; immunomodulation; blood-brain barrier; action mechanism
From: Medical Journal of Chinese People's Liberation Army 2024;49(11):1327-1335
CountryChina
Language:Chinese
Abstract: Traumatic Brain Injury(TBI)is a significant global cause of mortality and disability,severely compromising public health and quality of life.TBI can be divided into primary and secondary brain injuries according to pathological mechanism,with excessive infiltration of immune cells post-injury triggering neuroinflammation being one of the crucial mechanisms in the cascade of secondary brain injury.Currently,There is a lack of targeted therapeutic agents for TBI,and treatment mainly relies on symptomatic care.Mesenchymal stem cells(MSCs)have shown promising potential in the treatment of brain injury through their immune-modulatory properties,which can mediate immune responses to reduce neuroinflammation and repair nerve damage.The review summarizes the recent research progress on immune responses following TBI and the immune regulatory effects of MSCs,aiming to provide references for subsequent research and clinical applications.