Clinical management strategies for non-functional pituitary adenomas
10.11855/j.issn.0577-7402.0048.2024.0909
- VernacularTitle:无功能垂体腺瘤的临床管理策略
- Author:
Qian XU
1
;
Xiang HAN
;
Jing ZHAO
;
Hai-Bing JU
Author Information
1. 解放军联勤保障部队第920医院内分泌科,云南 昆明 650032
- Keywords:
non-functional pituitary adenomas;
pituitary function;
transsphenoidal surgery;
radiation therapy;
dopamine receptor agonists
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(11):1259-1265
- CountryChina
- Language:Chinese
-
Abstract:
Non-functional pituitary adenomas(NFPAs)are relatively common intracranial sellar tumors.The diagnostic rate of NFPAs has significantly increased in recent years due to the widespread application of computed tomography(CT)and magnetic resonance imaging(MRI)in clinical practice.NFPAs do not exhibit increased biochemical hormone secretion,so they may not present with obvious clinical manifestations.However,as the tumor grows,it can cause mass effect symptoms,such as headache,visual impairment,and related pituitary target gland dysfunction,and even life-threatening pituitary stroke.The evaluation of pituitary function in patients with NFPAs and the selection of treatment plans require close collaboration and scientific management by a multidisciplinary team.The genetic and epigenetic mechanisms underlying the occurrence and development of NFPAs have not yet been fully elucidated.New treatment strategies may be developed through technologies such as whole-genome sequencing combined with chromatin structure analysis.This review systematically summarizes the research progress in epidemiology,histopathology,clinical diagnosis,treatment,and prognosis of NFPAs,aiming to provide reference and guidance for clinical management.
