Research progress on autophagy dysfunction of vascular cells in the pathogenesis of atherosclerosis

VernacularTitle:血管细胞自噬功能失调在动脉粥样硬化发病机制中的研究进展
Author: Run-Min LIU ¹ ; Ke-Han WU ; Gao-Wei YANG ; Yu-Sheng WANG ; Hao WANG ; Tao RUI
Author Information

1. 江苏大学附属人民医院心血管内科/镇江市心肌疾病临床医学重点实验室,江苏镇江 212002
Keywords: atherosclerosis; autophagy; cardiovascular diseases
From: Medical Journal of Chinese People's Liberation Army 2024;49(10):1201-1206
CountryChina
Language:Chinese
Abstract: Autophagy is an essential cellular metabolic process that involves clearance of damaged organelles and protein aggregates in cells through lysosomes,providing energy for cells,and maintaining cellular tissue homeostasis.Impaired autophagy is closely related to the pathophysiology of a variety of diseases.In the pathogenesis of atherosclerosis(AS),the dysfunction of autophagy of vascular cells plays a crucial role in the formation and progression of AS.The functional status,survival or death of vascular cells,including endothelial cells,vascular smooth muscle cells and macrophages,can influence the formation and stability of plaques,thereby affecting the progression of AS.This review summarizes the relationship between autophagy and AS,and details the impact of autophagy dysfunction on vascular cell function in the process of AS,as well as the role of mitophagy and inflammasome in the development of AS,aiming to provide novel insights for the prevention and treatment of AS.