Research progress on the role and mechanism of IRAK4 in hematological malignancies
10.11855/j.issn.0577-7402.1579.2024.0418
- VernacularTitle:IRAK4在血液系统恶性肿瘤中的作用及其机制研究进展
- Author:
Ying SHANG
1
;
Li-Juan LI
;
Lian-Sheng ZHANG
Author Information
1. 兰州大学第二医院血液科,甘肃兰州 730030
- Keywords:
Interleukin-1 receptor associated kinase 4;
hematological malignancies;
pathogenesis;
targeted therapy
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(9):1094-1098
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-1 receptor associated kinase 4(IRAK4)plays a crucial role in signal transduction and regulation in the TLRs/IL-1R signaling pathway,coordinating multiple inflammatory pathways involving immune system activation,cytokine production,and cell proliferation and differentiation.IRAK4 is associated with the pathogenesis and progression of hematological malignancies,including myelodysplastic syndrome,acute myeloid leukemia,chronic lymphocytic leukemia,and lymphoma.Therefore,IRAK4 may serve as an effective therapeutic target for hematologic malignancies.This review summarizes the research advances in the structure and function of IRAK4,as well as its mechanism of action and therapeutic implications in hematological malignancies,aiming to provide insights into pathogenesis of related diseases and targeted therapy research.
