Research advances in endoplasmic reticulum autophagy and its roles in associated diseases
10.11855/j.issn.0577-7402.0217.2023.0719
- VernacularTitle:内质网自噬及其相关疾病研究进展
- Author:
Sen TONG
1
;
Ning DONG
;
Xiao-Mei ZHU
;
Yong-Ming YAO
Author Information
1. 解放军总医院医学创新研究部/第四医学中心,北京 100048
- Keywords:
endoplasmic reticulum stress;
autophagy;
reasearch progress
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(9):1062-1072
- CountryChina
- Language:Chinese
-
Abstract:
Endoplasmic reticulum is an important organelle in eukaryotic cells,which is responsible for the folding,processing and transportation of secretory proteins.A variety of stimuli inside and outside cells can lead to the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum,resulting in abnormal structure and function of the endoplasmic reticulum,which is called endoplasmic reticulum stress(ERS).Endoplasmic reticulum autophagy is an important endogenous mechanism to alleviate ERS.It is often considered as a cell protective procedure,which participates in many important physiological processes,such as metabolism,immune response,inflammatory response and cell proliferation.Endoplasmic reticulum autophagy is an important endogenous protective mechanism to alleviate endoplasmic reticulum stress and restore the endoplasmic reticulum homeostasis,through eliminating redundant and disabled endoplasmic reticulum membrane and macromolecular protein complexes,which is critical to cell function and fate.This paper reviews the types of endoplasmic reticulum autophagy,related specific receptors,main regulatory mechanisms,and its role and significance in the related diseases.
