Research progress on the role of TGR5 in cardiovascular diseases
10.11855/j.issn.0577-7402.0481.2024.0325
- VernacularTitle:TGR5在心血管疾病中的作用研究进展
- Author:
Xi YANG
1
;
Xiong-Shan SUN
;
Han LUO
;
Tao HU
;
Li ZHANG
;
Jia WANG
;
Qiang WANG
Author Information
1. 西南医科大学临床医学院,四川泸州 646000;西部战区总医院心血管内科,四川成都 610083
- Keywords:
Takeda G protein coupled receptor 5;
cardiovascular diseases;
atherosclerosis;
bile acid
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(6):711-717
- CountryChina
- Language:Chinese
-
Abstract:
Takeda G protein-coupled receptor 5(TGR5)is a bile acid receptor located on the surface of cell membrane,widely distributed in many tissues and cells in the body,and can be directly activated by most bile acids in vivo.TGR5 plays an important role in various physiological and pathophysiological processes,including cellular Ca2+transport,oxidative stress,cell proliferation,inflammatory responses,and mitochondrial metabolism,thereby maintaining mitochondrial homeostasis and vascular endothelial function,and inhibiting the progression of cardiovascular diseases such as atherosclerosis,myocardial hypertrophy,and cardiac remodeling after myocardial infarction.Currently,with the gradual clinical application of numerous bile acid and bile acid derivatives drugs,it is necessary to further investigate the role of TGR5 in the cardiovascular system,which is an important basis for clinical application of these new drugs.This review discusses the relationship between TGR5 and cardiovascular system from five perspectives:TGR5's involvement in regulating macrophages,endothelial function,vascular smooth muscle cells,cardiomyocytes,and mitochondrial metabolism.It summarizes the recent research progress,aiming to provide the theoretical basis for TGR5 as a novel therapeutic target for cardiovascular diseases.
