Research progress of vitamin D in neuro-developmental disabilities

VernacularTitle:维生素D在神经发育障碍性疾病中的作用研究进展
Author: Jia-Yang XIE ¹ ; Guo-Hui NIU
Author Information

1. 郑州大学第三附属医院儿童康复科/河南省儿科疾病临床医学研究中心,河南郑州 450052
Keywords: vitamin D; neuro-developmental disabilities; pathogenesis
From: Medical Journal of Chinese People's Liberation Army 2024;49(5):586-593
CountryChina
Language:Chinese
Abstract: Neuro-developmental disorders(NDDs)are chronic developmental brain dysfunctions that affect multifunctional areas of the brain,caused by various genetic or acquired factors.Vitamin D(Vit D),as a neurosteroid hormone,can exert its function through both genetic and non-genetic mechanisms.Over the past few decades,studies on the relationship between Vit D levels and NDDs have found that Vit D deficiency during development is a risk factor for some NDDs.Vit D deficiency in early life can affect brain development,disrupt the balance of neurotransmitters in the brain,and reduce the body's and brain's antioxidant capacity.This review examines the mechanism of Vit D in the brain,explores the relationship between Vit D and neurodevelopmental disabilities,highlights recent research progress and identifies unsolved problems,in order to deepen understanding of the role of Vit D in NDDs and provide novel insights for the diagnosis and treatment of NDDs.