Research advances in signal pathways related to active components of Psoralea corylifolia in osteoporosis
10.11855/j.issn.0577-7402.2279.2023.0620
- VernacularTitle:补骨脂活性成分治疗骨质疏松症的相关信号通路的研究进展
- Author:
Rui-Qi WU
1
;
Xiao-Yun ZHANG
;
Qi-Pei YANG
;
Qing-Lin PENG
Author Information
1. 广西中医药大学附属瑞康医院骨科,广西南宁 530011;广西中医药大学研究生院,广西南宁 530001
- Keywords:
Psoralea corylifolia;
osteoporosis;
oxidative stress;
bone resorption;
signal pathway
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(5):578-585
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis(OP)is a systemic bone disease characterized by low bone mass and damage to the microstructure of bone tissue,leading to increased bone fragility and susceptibility to fracture.Owing to its high prevalence,disability and mortality rates,as well as more sequelae,it brings heavy burden to patients and society.In recent years,as the research on the chemical and pharmacological effects of Psoralea corylifolia has made great progress,scholars have isolated compounds such as coumarins,flavonoids and monoterpene phenols,which have anti-OP,anti-oxidation,and anti-inflammatory properties,Psoralea corylifolia has been widely used in the treatment of OP.This article reviews the regulatory mechanism of active ingredients of Psoralea corylifolia in OP lipid metabolism,bone metabolism and oxidative stress,as well as related therapeutic strategies targeting Wnt/β-catenin,PI3K/Akt,PPAR-γ/Wnt,RANKL/RANK/MAPK and NF-κB signaling pathways,in order to provide further reference for the prevention and treatment of OP.
