The link between endoplasmic reticulum stress and glial cell activation-mediated neuroinflammation in epilepsy
10.11855/j.issn.0577-7402.0010.2023.0721
- VernacularTitle:内质网应激与胶质细胞激活介导的神经炎症在癫痫中的作用研究进展
- Author:
Sheng-Jie XU
1
;
Jia-Qiu XI
;
Xiao-Wen YU
;
Xiao-Fan MENG
;
Zhong-Lin WANG
Author Information
1. 山东中医药大学第一临床医学院,山东济南 250014
- Keywords:
epilepsy;
endoplasmic reticulum stress;
glial cell;
inflammatory response
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(4):475-481
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy is a chronic disease characterized by recurrent,sudden,and excessive synchronous discharge of neurons in the brain,leading to transient brain dysfunction,and inflammatory responses in specific regions within the central nervous system are common features of epilepsy.In recent years,there has been increasing evidence that endoplasmic reticulum stress is involved in the pathology of epilepsy,which activates the unfolded protein response,then regulate and control nuclear factor kappa-B(NF-κB),efficiently induces glial cell activation through the release of pro-inflammatory signals,in turn affects epileptogenesis and seizures by triggering neuroinflammation.This review focuses on the close link between endoplasmic reticulum stress and glial cell activation-mediated neuroinflammation in epilepsy pathology,aiming to provide insights for a deeper understanding of epilepsy.
