Research progress of histone deacetylase and its inhibitors in osteogenesis and odontogenic differentiation of odontogenic stem cells
10.11855/j.issn.0577-7402.2366.2023.0919
- VernacularTitle:组蛋白去乙酰化酶及其抑制剂在牙源性干细胞成骨和成牙本质分化中的研究进展
- Author:
Dong-Yu LI
1
;
Xiao-Miao ZHU
;
Ji-Rong ZHAO
;
Wen-Xi HE
Author Information
1. 延安大学生命科学学院,陕西延安 716000;军事口腔医学国家重点实验室/口腔疾病国家临床医学研究中心/陕西省口腔医学重点实验室/空军军医大学口腔医学院牙体牙髓病科,陕西西安 710032
- Keywords:
histone deacetylase;
histone deacetylase inhibitors;
odontogenic stem cells;
differentiation
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(4):468-474
- CountryChina
- Language:Chinese
-
Abstract:
Histone deacetylases(HDACs)can deacetylate histones,leading to tighter DNA binding,and thereby playing a role in inhibiting gene transcription.On the contrary,histone deacetylase inhibitors(HDACis)can promote chromatin relaxation,enabling various transcription factors to bind specifically to DNA and activate transcription genes.Dental stem cells(DSCs)are human adult stem cells.These cells have the characteristics of less damage and low immune rejection during sampling,and are especially important seed cells in the process of osteogenesis,odontogenesis and other differentiation.A large number of experimental studies have shown that HDACs and HDACis together play important roles in cell division and differentiation,signal transduction,regulation of cellular inflammation and other life processes.This review summarizes the research progress of HDACs and HDACis in regulating osteogenic and odontogenic differentiation of DSCs,aiming to provide insights into the study of the interaction between HDACs and HDACis,and potentially guide clinical application of DSCs in the treatment of tooth and bone injury.
