Research progress on protein translational reprogramming in tumors
10.16352/j.issn.1001-6325.2024.12.1736
- VernacularTitle:蛋白质翻译重编程在肿瘤中的研究进展
- Author:
Ying FAN
1
;
Yang LIU
;
Yanyong LIU
Author Information
1. 西藏大学 医学院,西藏 拉萨 850000;中国医学科学院基础医学研究所 北京协和医学院基础学院 药理学系,北京 100005
- Keywords:
protein translation;
translational reprogramming;
epithelial-mesenchymal transition;
tumor drug resistance
- From:
Basic & Clinical Medicine
2024;44(12):1736-1740
- CountryChina
- Language:Chinese
-
Abstract:
Protein translational reprogramming is an important compensatory change made by cells in response to a variety of stimuli,resulting in rapid,specific changes to the cellular proteome.In tumor cells,this reprogramming is regulated through several mechanisms,including the internal ribosome entry site(IRES),cap-independent translational enhancers(CITE),and N6-methyladenosine(m6A)modifications.These processes play pivotal roles in controlling protein translational reprogramming,which is essential for tumorigenesis,progression,and treatment resistance.Further research into the function of protein translational reprogramming in tumors may reveal novel ther-apeutic targets and offer new avenues for cancer treatment.
