Role of neutrophils and NETs in osteosarcoma and soft tissue sarcoma
10.16352/j.issn.1001-6325.2024.10.1442
- VernacularTitle:中性粒细胞及NETs在骨与软组织肉瘤中的作用
- Author:
Qinrong ZHANG
1
;
Chunxia LIU
Author Information
1. 广州医科大学附属第二医院 病理科,广东 广州 510260
- Keywords:
osteosarcoma;
soft tissue sarcoma;
neutrophil;
neutrophil extracellular traps;
tumor-associated neutrophils
- From:
Basic & Clinical Medicine
2024;44(10):1442-1446
- CountryChina
- Language:Chinese
-
Abstract:
Neutrophils are one of the important components of the tumor microenvironment.Neutrophil extra cellular traps(NETs)are a network structure released by neutrophils,and their formation process is called neutrophil in-flammatory apoptosis(NETosis).Neutrophils in the tumor microenvironment,also known as tumor associated neu-trophils(TANs).TANs including N1 phenotype and N2 phenotype have a bidirectional regulatory effect on tumors.While N1 phenotype inhibits tumor growth,and N2 phenotype promotes tumor growth,and N1 and N2 types under-go mutual transformation due to the influence of the tumor microenvironment.Neutrophils and NETs also play im-portant roles in bone and osteosarcoma tissue sarcoma,which can affect tumor progression and predict patient prog-nosis.Blocking the formation of NETs may be a potential therapeutic target.
