Research progress of brain organoids in drug development
10.16352/j.issn.1001-6325.2024.09.1208
- VernacularTitle:脑类器官在药物研发中的研究进展
- Author:
Liang WANG
1
;
Longkuo XIA
;
Jianmin ZHANG
Author Information
1. 国典 (北京) 医药科技有限公司,北京 100176
- Keywords:
brain organoids;
disease model;
drug screening;
precision therapy
- From:
Basic & Clinical Medicine
2024;44(9):1208-1213
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,with rapid development of technology of regenerative medicine and tissue engineering,brain organoids,as an innovative in vitro model system,have become a hot spot in neuroscience research and drug development.Brain organoids simulate the complex structure and function of the human brain in terms of reprodu-cing key processes of brain development in vitro,providing an unprecedented platform for understanding the mecha-nisms of neurological diseases and of evaluating drug efficacy and toxicity.This review summarizes the latest re-search progress in brain organoid technology,particularly its application in drug development and in exploring chal-lenges and orientation of future development.
