Role of SphK/S1P in cardiovascular diseases
10.16352/j.issn.1001-6325.2024.08.1175
- VernacularTitle:SphK/S1P在心血管疾病中的作用
- Author:
Lihong TANG
1
;
Chunling CHEN
Author Information
1. 新疆医科大学第一附属医院麻醉科,新疆乌鲁木齐 830054
- Keywords:
sphingosine-1-phosphate;
sphingosine kinase;
cardiovascular diseases;
endothelial glycocalyx layer
- From:
Basic & Clinical Medicine
2024;44(8):1175-1179
- CountryChina
- Language:Chinese
-
Abstract:
Sphingosine-1-phosphate(S1P)is a highly active membrane phospholipid metabolite with important physiological roles in the cardiovascular system.Sphingosine kinase(SphK)is a lipase that is important for main-taining stable S1P levels in vivo.S1P exerts different physiological effects in cardiovascular diseases by catalytically regulating the binding of S1P to G protein-coupled receptors(S1PR1-5)on the cell surface,thus exerting different physiological effects in cardiovascular diseases.For example,they are involved in regulating the development of dis-eases such as atherosclerosis,myocardial ischemia-reperfusion injury,myocardial infarction,heart failure and other diseases,maintaining the barrier function of vascular endothelial cells,protecting the endothelial glycocalyx layer,leukocyte adhesion,inflammatory reactions and other pathophysiologic processes.
