Inflammatory cells and vascular remodeling in pulmonary arterial hypertension
10.16352/j.issn.1001-6325.2024.08.1080
- VernacularTitle:炎性细胞与动脉性肺动脉高压血管重塑
- Author:
Xifeng QIAN
1
;
Lu HUA
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 国家心血管疾病临床研究中心肺血管医学重点实验室,北京 100037
- Keywords:
pulmonary arterial hypertension;
pulmonary vascular remodeling;
inflammation;
inflammatory cells
- From:
Basic & Clinical Medicine
2024;44(8):1080-1087
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary arterial hypertension(PAH)is a severe and progressive pulmonary vascular disease mainly characterized by a continuous increase in pulmonary vascular resistance and rise of pulmonary artery pressure caused by pulmonary arteriolar lesions,ultimately resulting in right heart failure and even death.Pulmonary vascular remodeling is a characteristic pathological change of PAH,and its mechanism involves gene susceptibility,imbalance of vasoactive substances,abnormal energy metabolism and other potential factors.Recent studies have found that inflammatory reaction plays a crucial role in the mechanism of pulmonary vascular remodeling.Inflamma-tory cells are found to infiltrate and accumulate around the pulmonary vessels of PAH patients and of animal models.In addition,significantly high level of cytokines and auto-antibodies were also found in peripheral blood,which is closely related to poor prognosis of PAH.This article reviews the research progress about the potential role of in-flammatory cells in the vascular remodeling of PAH and provides new ideas for developing of safe and effective treatment methods for PAH.
