Research progress on the role of FOXC1 in the development of digestive system cancer

VernacularTitle:FOXC1在消化系统癌发生发展中作用的研究进展
Author: Qing JIN ¹ ; Youming DING
Author Information

1. 武汉大学第一临床学院,武汉 430000
Keywords: the FOX family; FOXC1; digestive system cancers; signal pathway
From: Basic & Clinical Medicine 2024;44(7):1049-1053
CountryChina
Language:Chinese
Abstract: forkhead box protein C1(FOXC1)is a cancer-related transcription factor that plays an important role in various signaling pathways related to cancer development.FOXC1 is involved in the regulation of cancer cells from many aspects,including proliferation,metastasis and recurrence.FOXC1 can promote cell cycle progression and cell proliferation by up-regulating the expression of oncogenes,such as cyclin D1.FOXC1 promotes epithelial-mes-enchymal transition(EMT),in which cells change from polarized epithelial cells to cells with stromal characteris-tics,which contributes to tumor cell infiltration and migration.FOXC1 may play a role in tumor angiogenesis by reg-ulating genes associated with angiogenesis.FOXCI can enhance cell migration and invasion by regulating reactive ox-ygen species and activating β-catenin expression.In summary,FOXC1 functions through a variety of mechanisms.