Metabolic abnormalities in hyperoxia-induced lung diseases of neonates
10.16352/j.issn.1001-6325.2024.07.1034
- VernacularTitle:新生儿高氧相关肺疾病的代谢异常
- Author:
Guangliang HE
1
;
Tao WANG
;
Lei LIU
;
Jian ZHOU
;
Min YE
Author Information
1. 海南科技职业大学 国际护理学院,海南 海口 571126;西南医科大学合江医院 呼吸与危重症医学科,四川 泸州 646000
- Keywords:
newborn;
hyperoxia;
lung disease;
metabolic abnormalities;
mitochondria
- From:
Basic & Clinical Medicine
2024;44(7):1034-1038
- CountryChina
- Language:Chinese
-
Abstract:
High oxygen(hyperoxia)concentration may damage multiple organs and systems in newborns,such as the lung,brain and intestines.Metabolic abnormalities are important early events in the pathogenesis of neonatal hyperoxia related pulmonary diseases.This article reviews the increased glucose and lipid metabolism as well as dys-regulation of amino acid metabolism after hyperoxia related bronchopulmonary dysplasia in newborns.The potential mechanism may be that the high oxygen concentration increases formation of mitochondrial reactive oxygen species(mtROS),and also change the mitochondrial dynamics of neonatal bronchopulmonary dysplasia,leading to reduc-tion of mitochondrial fusion,enhances fission and autophagy.This study also finds that many metabolism-related en-zymes and metabolites are changed during hyperoxia related diseases.However,clinical research has not yet been conducted.Future research should focus on combining metabolic profiles with multi omics data,including transcrip-tome sequencing,genomics and proteomics to identify potential biomarkers and therapeutic targets for hyperoxia related neonatal lung injury in order to develop new strategies for the treatment of metabolic abnormalities resulted from neonatal hyperoxia related pulmonary diseases.
