Mitophagy in hepatic ischemia-reperfusion injury
10.16352/j.issn.1001-6325.2024.06.0877
- VernacularTitle:线粒体自噬在肝脏缺血再灌注损伤中的作用
- Author:
Xiangxin ZHANG
1
;
Wen LI
Author Information
1. 首都医科大学,北京 100069
- Keywords:
hepatic ischemia-reperfusion injury(HIRI);
mitophagy;
mitochondrial dynamic related protein
- From:
Basic & Clinical Medicine
2024;44(6):877-881
- CountryChina
- Language:Chinese
-
Abstract:
In case of hepatic ischemia-reperfusion injury(HIRI),mitophagy is induced by multiple pathways such as PINK1/Parkin and mitophagy receptor,which is closely related to mitochondrial dynamic related protein.Mito-phagy is a double-edged sword.Moderate mitophagy is effective in reducing the oxidative stress and maintaining mi-tochondria homeostasis,thereby reducing hepatocyte apoptosis and necrosis,inhibiting inflammation response and mitigating HIRI.However excessive mitophagy will aggravate HIRI.So research on the role and mechanism of mito-phagy may facilitate the development of new strategy for prevention and clinical treatment of HIRI.
