Mechanisms of cell death and proliferation of aldosterone-producing adenoma
10.16352/j.issn.1001-6325.2024.06.0758
- VernacularTitle:醛固酮产生腺瘤中细胞死亡和增殖机制
- Author:
Yinjie GAO
1
;
Anli TONG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院 内分泌科 国家卫生健康委员会内分泌重点实验室,北京 100730
- Keywords:
primary aldosteronism;
aldosterone-producing adenoma;
cell proliferation and apoptosis;
signaling pathway;
multi-omics study
- From:
Basic & Clinical Medicine
2024;44(6):758-762
- CountryChina
- Language:Chinese
-
Abstract:
Aldosterone-producing adenoma(APA)is one of the main causes of primary aldosteronism(PA).Cur-rent researches on its autonomous secretion of aldosterone mainly focus on the detection of somatic driver genetic mutations.However,the specific mechanisms underlying the death and proliferation of adrenal cortical cells and the occurrence and development of adenomas are still unclear.This study aims to review the research progress on the mechanisms of cell death and proliferation of APA by combining previously published studies on genomics,tran-scriptomics,metabolomics,and epigenetics related to adrenal tissues.
