Genetic and molecular mechanism changes of adrenocortical carcinoma
10.16352/j.issn.1001-6325.2024.06.0748
- VernacularTitle:肾上腺皮质癌基因及分子机制
- Author:
Jinghua LIU
1
;
Lin LU
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院 内分泌科 国家卫生健康委员会内分泌重点实验室,北京 100730
- Keywords:
adrenocortical carcinoma;
adrenocortical development;
molecular mechanism;
multiple omics studies
- From:
Basic & Clinical Medicine
2024;44(6):748-752
- CountryChina
- Language:Chinese
-
Abstract:
Adreno-cortical carcinoma(ACC)is an uncommon tumor,some of them may produce excessive steroid hormone.The prognosis of ACC is quite poor and current treatment options are relatively limited,especially for pa-tients whose tumor is metastatic and difficult to remove by surgical operation.This makes the management of ACC challenging.Existing studies have shown that the mechanisms of ACC are complex.The molecular changes happen in adrenocortical development and homeostasis may explain the occurrence of ACC.This review focuses on recent studies and summarizes the genetic and molecular mechanism changes that potentially associated with ACC in the development process of the adrenal cortex and multi-omics studies,including genomic changes,epigenetic changes,differences in non-coding RNA,immune microenvironment and features found through multi-omics analy-sis.This information may support screening of therapeutic targets of ACC in future.
