Exploration of the Medication Rules of Chinese Medicine for the Treatment of Ulcerative Colitis at Remission Stage Based on Data Mining
10.13359/j.cnki.gzxbtcm.2024.09.038
- VernacularTitle:基于数据挖掘探讨中药治疗溃疡性结肠炎缓解期的用药规律
- Author:
Xia TIAN
1
;
Cai-Ling ZHONG
;
Xu-Jie XI
;
Bei-Ping ZHANG
Author Information
1. 广州中医药大学第二临床医学院,广东广州 510006
- Keywords:
ulcerative colitis;
remission stage;
Atractylodis Macrocephalae Rhizoma;
Poria;
Aucklandiae Radix;
Coptidis Rhizoma;
Shenling Baizhu San;
Sishen Pills;
strengthening the spleen and removing dampness;
data mining
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(9):2483-2490
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the medication rules of tradition Chinese medicine for the treatment of ulcerative colitis(UC)at remission stage by data mining method,thus to provide reference for clinical prescription and medication.Methods The clinical research or medical case report of UC remission treated by Chinese medicine issued in CNKI,Wanfang Data and VIP from July 2000 to December 2022 were retrieved.Excel 2019 was used to analyze the frequency statistics,and the distribution of the nature,flavor and meridian tropism of the prescribed drugs in the included literature.Modeler 18.0 and SPSS Statistics 26.0 were used for association rules and cluster analysis,and Cytoscape 3.9.1 was used to construct the network diagram of the associated drugs.Results A total of 121 articles were included in the analysis,involving 167 drugs,of which 24 drugs were frequently used,mainly including Atractylodis Macrocephalae Rhizoma,Poria,Aucklandiae Radix,Coptidis Rhizoma,Codonopsis Radix,Paeoniae Radix Alba,Coicis Semen,Astragali Radix,Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,Angelicae Sinensis Radix,Citri Reticulatae Pericarpium,and Dioscoreae Rhizoma.According to the therapeutic actions,the drugs were mainly classified into deficiency-supplementing drugs,heat-clearing drugs,qi-regulating drugs,urination-promoting and dampness-percolating drugs,blood-stanching drugs,exterior-relieving drugs,interior-warming drugs,astringent drugs,dampness-resolving drugs,and blood-activating and stasis-resolving drugs.The medicinals were mainly warm,mild and cold in nature,and were sweet,bitter and pungent in flavor.Most of the drugs had the meridian tropism of the spleen,stomach,lung and liver.A total of 25 drug association rules were mined out,and five prescriptions were obtained after cluster analysis.Conclusion The Chinese medicine prescriptions for the treatment of UC remission usually deprive from the classical formulas such as Shenling Baizhu San,Sishen Pills,and Tongxie Yaofang.The compatibility of drugs reflects the thoughts of treating UC remission from the perspective of spleen,and embodies the therapies of strengthening the spleen and removing dampness,promoting qi and regulating blood,and focusing on tonifying ministerial fire and supporting yang in the later stage,which has the characteristics of treating both symptoms and root causes simultaneously by using multiple drugs through multiple methods.
