Exploration of the Pathogenesis of Inflammation-to-Tumor Transition in Chronic Atrophic Gastritis and Thoughts for Its Syndrome Differentiation and Treatment by LIU Feng-Bin
10.13359/j.cnki.gzxbtcm.2024.07.033
- VernacularTitle:刘凤斌对慢性萎缩性胃炎"炎-癌"转化的病机探索与辨治思路
- Author:
Xiao-Tao JIANG
1
;
Pei-Wu LI
;
Ze-Hong YANG
;
Jin-Qi AN
;
Yuan-Cheng HUANG
;
Yi WEN
;
Feng-Bin LIU
Author Information
1. 广州中医药大学第一临床医学院,广东广州 510006
- Keywords:
chronic atrophic gastritis;
inflammation-to-tumor transition;
traditional Chinse medicine(TCM)pathogenesis;
weakness of the spleen and stomach;
qi stagnation;
blood stasis;
dampness retention;
thoughts for syndrome differentiation and treatment;
LIU Feng-Bin
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(7):1880-1885
- CountryChina
- Language:Chinese
-
Abstract:
Chronic atrophic gastritis(CAG)is a common intractable gastric disease in clinic,which belongs to the gastric precancerous lesions.Professor LIU Feng-Bin and his team have performed the exploration and practice in the field of CAG for more than 30 years,and they proposed that the evolution of the traditional Chinse medicine(TCM)pathogenesis of inflammation-to-tumor transition(ITT)in CAG was characterized by spleen deficiency being the root cause,qi stagnation,blood stasis and dampness retention being the branch cause,and stasis and toxin being the aggravating factors.Deificiency of the spleen and stomach is the initial factor of CAG,which influences the whole process of the disease.Qi stagnation,blood stasis and dampness retention are the triggering and aggravating factors for the ITT in CAG.The formation of blood stasis and toxin is the key to the progression and transition of CAG.Treatment of ITT in CAG should be based on the results of syndrome differentiation and gastroscopic findings by staging therapy.Before treatment,disease dianosis and syndrome differentiation should be made,and macro and micro syndrome differentiation should be carried out for assistance.Therapy of strengthening the spleen and supporting healthy qi should be implemented throughout the whole process of the disease.The early stage of CAG has the features of gastric mucosa with mild to moderate atrophy and with or without mild intestinal epithelial hyperplasia,the pathogenesis of early CAG is characterized by weakness of the spleen and stomach and is accompanied with the pathological factors of qi stagnation,damp-retention and blood stasis,and the basic treatment should adopt the therapies of strengthening the spleen and clearing heat,regulating qi and activating blood stasis.The advanced stage of CAG has the features of severe atrophic gastric mucosa with or without moderate to severe intestinal epithelial and/or mild to moderate intraepithelial neoplasia,the pathogenesis is characterized by weakness of the spleen and stomach,phlegm blended with blood stasis,and stasis-toxin in the gastric collaterals,and the basic treatment should adopt the therapies of supporting healthy qi and dissipating masses,and unblocking the collaterals and removing toxin,so as to construct an intact line to blocking the ITT in CAG with traditional Chinese medicine.
