Preparation and Performance Characterization of Microcapsules Containing Ethanol Extract from Galangal
10.13359/j.cnki.gzxbtcm.2024.05.032
- VernacularTitle:高良姜乙醇提取物微囊的制备及其性能表征
- Author:
Su-Juan PENG
1
;
Zhen-Rong WEN
;
Zhen-Ying FENG
;
Dan CHEN
;
Jian-Wen WANG
;
Li-Ping HUANG
Author Information
1. 广东医科大学附属第二医院,广东湛江 524001
- Keywords:
galangal;
microcapsules;
composite coacervation method;
preparation process;
performance characterization
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(5):1307-1315
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the best preparation process and performance characterization of microcapsules containing ethanol extract from galangal.Methods With gum arabic(GA)-chitosan(CS)as capsule wall material,microcapsules were prepared by complex coacervation method.With drug loading and encapsulation efficiency as indexes,the optimal preparation technology of microcapsules was screened by orthogonal design method.The content of ethanol extract of galangal in microcapsules was determined by high performance liquid chromatography(HPLC).The prepared microcapsules were characterized by infrared spectrometer and scanning electron microscope.Results The optimum preparation conditions of microcapsules containing galangal ethanol extract were as follows:wall material ratio(GA/CS)6∶1,core to wall ratio 1∶1,coagulation time 45 minutes,curing agent dosage 3 mL.Under these conditions,the drug loading and encapsulation efficiency of microcapsules containing galangal ethanol extract were 27.17%and 80.07%,respectively,and the sustained release performance of microcapsules of galangal ethanol extract was superior to that of galangal ethanol extract.Conclusion The preparation of microcapsules containing galangal ethanol extract by complex coacervation method has good encapsulation,and the method is simple,stable and reliable,and has high feasibility.
