Discussion on the pathological mechanism of atherosclerotic vulnerable plaque formation based on the theory of heart toxicity of heat diseases
10.3760/cma.j.cn115398-20231201-00005
- VernacularTitle:基于心系疾病热毒学说探讨动脉粥样硬化易损斑块形成的病理机制
- Author:
Lele QIN
1
;
Wenge SU
;
Zhen HUA
Author Information
1. 山东中医药大学中医学院2021级硕士研究生，济南 250014
- Keywords:
Plaque, atherosclerotic;
Cardiovascular diseases;
Heat-toxicity theory;
Theoretical discussion
- From:
International Journal of Traditional Chinese Medicine
2024;46(11):1401-1405
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerotic plaque is an important cause of unstable angina pectoris, and its etiology and pathogenesis have always been a hot topic in cardiovascular field. The theory of heat toxicity of heart diseases is based on pathological factors "heat toxicity", which is the improvement of TCM pathogenesis of coronary atherosclerotic heart disease by modern TCM theory system, and provides a new theoretical basis for the TCM diagnosis and treatment of clinical coronary heart disease. As the TCM cause and pathological product of coronary heart disease, "heat toxicity" runs through the diagnosis and treatment process of coronary heart disease. In the pathophysiology of Western medicine, atherosclerotic plaque is the key cause of unstable angina pectoris and acute coronary syndrome, which involves inflammation, pyroptosis, apoptosis and cell burial. However, the theoretical discussion of acute cardiovascular events corresponding to TCM is limited to normal yang collapse, heart-yang outburst and so on. Therefore, starting from the theory of heat toxicity of heart diseases, this article aimed to explore the connection between the formation process of atherosclerotic vulnerable plaque in Western pathophysiology and the long-term fumigation of blood vessels by "heat toxicity" in the etiology and pathogenesis of TCM. On this basis, it proposed the diagnosis and treatment idea of treating clinically unstable angina pectoris with the method of clearing heat and detoxification, that is, stabilizing plaque by clearing heat and detoxification, in order to provide new methods and new ideas for clinical diagnosis and treatment.
