Diagnostic value of detection of serum G-17, sB7-H3, and DKK1 for early gastric cancer
10.3760/cma.j.cn371439-20240304-00083
- VernacularTitle:血清G-17、sB7-H3、DKK1检测对早期胃癌的诊断价值
- Author:
Wenhui LIU
1
;
Ping YIN
;
Jie QI
Author Information
1. 中国人民解放军陆军第八十一集团军医院体检科，张家口 075000
- Keywords:
Stomach neoplasms;
Gastrins;
Soluble B7-H3;
Dickkopf-1;
Diagnosis
- From:
Journal of International Oncology
2024;51(8):498-503
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the diagnostic value of detection of serum gastrin-17 (G-17), soluble B7-H3 (sB7-H3), and Dickkopf-1 (DKK1) in early gastric cancer (EGC) .Methods:A total of 95 patients with EGC admitted to the Hospital of 81st Group Army of the Chinese People's Liberation Army from April 2021 to April 2023 were selected as the EGC group, 95 gastritis patients as the gastritis group, and 95 healthy individuals as the control group. The serum levels of G-17, sB7-H3, and DKK1 were compared among the three groups of subjects, and serum G-17, sB7-H3 and DKK1 levels of patients with different pathological characteristics in EGC group were also compared. Receiver operator characteristic (ROC) curve was applied to analyze the diagnostic value of serum G-17, sB7-H3, and DKK1 levels for EGC. Multivariate logistic regression was applied to analyze the risk factors of EGC.Results:The proportions of Helicobacter pylori infection in the control group, gastritis group, and EGC group were 20.00% (19/95), 35.79% (34/95), and 61.05% (58/95), respectively, with a statistically significant difference ( χ2=34.26, P<0.001). The serum G-17 levels were (6.98±0.55), (8.39±0.95), and (9.46±1.38) pmol/L, respectively, with a statistically significant difference ( F=141.82, P<0.001). The levels of sB7-H3 were (18.86±1.64), (20.34±2.16), (22.44±2.62) ng/ml, respectively, with a statistically significant difference ( F=64.86, P<0.001). The levels of DKK1 were (12.87±1.96), (14.75±2.09), (6.93±2.24) ng/ml, respectively, with a statistically significant difference ( F=88.95, P<0.001). Pairwise comparison showed that the proportion of Helicobacter pylori infection in the control group, gastritis group and EGC group increased in turn, and the levels of serum G-17, sB7-H3 and DKK1 increased in turn (all P<0.05). There were no significant difference in age and gender between EGC patients with different serum G-17, sB7-H3 and DKK1 levels (all P>0.05), and there were statistically significant differences in tumor diameter ( χ2=5.74, P=0.017; χ2=4.98, P=0.026; χ2=5.74, P=0.017), tumor invasion ( χ2=10.94, P=0.001; χ2=16.16, P<0.001; χ2=21.16, P<0.001), lymph node metastasis ( χ2=6.75, P=0.009; χ2=10.68, P=0.001; χ2=4.74, P=0.029) and differentiation type ( χ2=7.00, P=0.008; χ2=4.26, P=0.039; χ2=27.18, P<0.001). ROC curve analysis showed that the area under the curve (AUC) of G-17, sB7-H3 and DKK1 in the diagnosis of EGC was 0.825, 0.763 and 0.785, respectively. The AUC of the combined detection of the three indicators was 0.933, which was better than that of the three separate tests ( Z=3.22, P=0.001; Z=4.94, P<0.001; Z=4.53, P<0.001). Multivariate logistic regression analysis showed that the levels of G-17 ( OR=3.82, 95% CI: 1.73-8.44, P<0.001), sB7-H3 ( OR=3.96, 95% CI: 1.75-8.96, P<0.001), DKK1 ( OR=3.85, 95% CI: 1.77-8.41, P<0.001) were the independent risk factors of EGC. Conclusion:Serum G-17, sB7-H3, and DKK1 have certain auxiliary diagnostic value of three indexes for EGC, and the combined detection value is higher.
