Application progress of decellularized extracellular matrix in myocardial infarction treatment
10.3760/cma.j.cn121382-20240510-00512
- VernacularTitle:脱细胞基质材料在心肌梗死治疗中的应用进展
- Author:
Qingyu WANG
1
;
Jing LIU
;
Zhihong WANG
;
Hailing ZHANG
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Decellularized extracellular matrix;
Tissue engineering;
Myocardial infarction;
Myocardial repair
- From:
International Journal of Biomedical Engineering
2024;47(5):492-496
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction is one of the major diseases that seriously threaten human health. In the clinical treatment of myocardial infarction, there are unpredictable complications, and most patients will suffer a severe cardiac function decline due to excessive loss of myocardia and formation of scar tissue, eventually progressing to heart failure or even death. With rapid development of biological materials, they as an important part of tissue repair and regeneration research, have become a hot spot in the research and development of cardiovascular repair materials. Among them, decellularized extracellular matrix (dECM) materials, a class of natural materials with good histocompatibility, low immunogenicity, and suitable cell growth and metabolism characteristics, have been applied in clinical or preclinical cardiovascular tissue engineering or regenerative medicine. In this review, the application progress of dECM materials in tissue engineering, including the dECM preparation of 3D printed bioink, electrospinning, matrix hydrogel, and myocardial patch, in myocardial infarction treatment was summarized, and prospects and current challenges in the treatment of myocardial infarction were discussed.
