Research progress in mechanism of action of extracellular vesicle drug delivery system in the treatment of abdominal tumors
10.3760/cma.j.cn121382-20240124-00215
- VernacularTitle:细胞外囊泡载药系统治疗腹部肿瘤作用机制的研究进展
- Author:
Huichao YANG
1
;
Jing XUN
;
Ximo WANG
;
Hui ZHANG
;
Dapeng ZHANG
;
Qi ZHANG
Author Information
1. 天津医科大学附属南开医院，天津市中西医结合急腹症研究所，天津市急腹症器官损伤与中西医修复重点实验室，天津 300100
- Keywords:
Extracellular vesicles;
Drug delivery system;
Abdominal tumor;
Resistance;
Immune microenvironment
- From:
International Journal of Biomedical Engineering
2024;47(2):200-204
- CountryChina
- Language:Chinese
-
Abstract:
Traditional drugs for the treatment of abdominal tumors often do not have the ability to target tumors and destroy normal cells while killing tumor cells. Therefore, new therapies are urgently needed to accurately target and kill tumor cells. As a drug carrier, extracellular vesicles have the advantages of naturalness, biotaxis, and low side effects, so they have attracted much attention in the research on the treatment of abdominal tumors. In this paper, the research progress in mechanism of action of extracellular vesicle drug delivery system in the treatment of abdominal tumors such as gastric, liver, pancreatic, bile duct, colorectal, and ovarian cancers with an extracellular vesicle drug delivery system was reviewed, including inhibiting the growth of abdominal tumor cells, reversing the drug resistance of the tumor stem cells, inhibiting the exocytosis of chemotherapeutic drugs from the tumor cells, and remodeling the tumor immune microenvironment.
