Correlation between serum sFGL2,AFABP and the severity and prognosis of patients with chronic heart failure
10.3969/j.issn.1673-4130.2024.22.019
- VernacularTitle:慢性心力衰竭患者血清sFGL2、AFABP与心力衰竭严重程度及预后的相关性研究
- Author:
Chunjuan ZHANG
1
;
Hongkun LI
Author Information
1. 唐山市人民医院功能科,河北唐山 063000
- Keywords:
chronic heart failure;
soluble fibrinogen like protein 2;
adipocyte fatty acid-binding pro-tein;
severity;
prognosis
- From:
International Journal of Laboratory Medicine
2024;45(22):2784-2788
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum soluble fibrinogen like protein 2(sFGL2)and adipocyte fatty acid-binding protein(AFABP)with the severity and prognosis of patients with chronic heart failure.Methods A total of 102 confirmed chronic heart failure patients treated in Tangshan People's Hospital(the hospital)from June 2020 to June 2022 were regarded as the disease group.They were divided into grade Ⅱ group(28 cases),grade Ⅲ group(35 cases),and grade Ⅳ group(39 cases)based on their illness severity.They were separated into MACE group(44 cases)and non MACE group(58 cases)based on their prognosis.Additionally,102 healthy individuals who came to Tangshan People's Hospital for physical examination were regarded as the control group.The levels of serum sFGL2 and AFABP in each group were compared.Logistic regression was applied to analyze the influencing factors of poor prognosis in patients.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum sFGL2 and AFABP levels for poor prognosis in patients.Results Compared with the control group,the serum sFGL2 level in the diseased group was greatly reduced(P＜0.05),while the AFABP level was greatly in-creased(P＜0.05).The serum sFGL2 level in grade Ⅱ group,grade Ⅲ group,and grade Ⅳ group decreased sequentially(P＜0.05),while the AFABP level increased sequentially(P＜0.05).The heart rate and sFGL2 level in the MACE group were greatly lower than those in the non MACE group(P＜0.05),while the propor-tion of atrial fibrillation and AFABP level were greatly higher than those in the non MACE group(P＜0.05).Heart rate,atrial fibrillation,and AFABP were independent risk factors for MACE in patients(P＜0.05),while sFGL2 was an independent protective factor for MACE in patients(P＜0.05).The area under the curve(AUC)of serum sFGL2 and AFABP for predicting MACE in patients was 0.842 and 0.858,respectively,the AUC of the combination of the two was 0.943,and the combined prediction of the two was better than the in-dividual prediction(Zcombined prediction-sFGL2=2.898,P=0.004;Zcombinedprediction-AFABP=2.608,P=0.009).Conclusion Ser-um sFGL2 level is down regulated and AFABP level is up regulated in patients with chronic heart failure,which are influencing factors for the occurrence of MACE.The combination of the two has higher efficacy in predicting the prognosis of the patients.
