Relationship between serum calcineurin 6 and calcineurin 11 levels and adverse pregnancy outcome in patients with early-onset severe preeclampsia
10.3969/j.issn.1673-4130.2024.21.008
- VernacularTitle:早发型重度子痫前期患者血清钙黏素6、钙黏素11水平与不良妊娠结局的关系
- Author:
Xiangyang ZHAO
1
;
Yanhua WANG
;
Yanan WEI
Author Information
1. 汉中市人民医院妇产科,陕西汉中 723000
- Keywords:
early-onset severe preeclampsia;
cadherin 6;
cadherin 11;
adverse pregnancy outcome
- From:
International Journal of Laboratory Medicine
2024;45(21):2600-2604,2609
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum levels of calcineurin(CDH)6 and CDH11 and adverse pregnancy outcomes in patients with early-onset severe preeclampsia(EOSP).Methods A total of 100 patients with EOSP admitted to the hospital from January 2022 to May 2023 were se-lected as the EOSP group and 88 healthy pregnant women who underwent pregnancy test at the hospital dur-ing the same period were selected as the control group.The patients with EOSP were divided into the poor outcome group(61 patients)and the good outcome group(39 patients)according to the pregnancy outcome.Serum CDH6 and CDH11 levels were measured by enzyme-linked immunosorbent assay.Multivariate Logistic regression was used to analyze the factors of adverse pregnancy outcomes in patients with EOSP,and receiver operating characteristic curve was used to analyze the predictive value of serum CDH6 and CDH11 levels for adverse pregnancy outcomes in patients with EOSP.Results Serum CDH6[223.78(172.58,664.76)ng/mL]and CDH11[3.36(3.09,4.55)ng/mL]levels were higher in the EOSP group than those in the control group[90.93(74.24,362.81)ng/mL]and[1.33(1.06,3.74)ng/mL],and the differences were statistically significant(P＜0.05).The incidence of adverse pregnancy outcome in 100 EOSP patients was 61.00％(61/100).Serum CDH6[239.93(214.38,797.17)ng/mL]and CDH11[4.12(3.37,12.96)ng/mL]levels were higher in the poor outcome group than in the good outcome group[184.14(139.82,223.64)ng/mL]and[3.23(2.52,3.75)ng/mL],and the differences were statistically significant(P＜0.05).Elevated urinary protein(OR=1.019,95％CI:1.000-1.037),CDH6(OR=1.003,95％CI:1.001-1.005),and CDH11(OR=3.477,95％CI:1.432-8.441)were independent risk factors for adverse pregnancy outcomes in pa-tients with EOSP(P＜0.05).The area under the curve of combined detection of serum CDH6 and CDH11 levels for predicting adverse pregnancy outcomes in EOSP patients was 0.864(95％CI:0.810-0.943),which was greater than 0.786(95％CI:0.692-0.861)and 0.790(95％CI:0.697-0.865)of serum CDH6 and CDH11 alone,and the differences were statistically significant(P＜0.05).Conclusion Elevated serum CDH6 and CDH11 levels in patients with EOSP are independent risk factors for adverse pregnancy outcomes in pa-tients with EOSP,and the combined detection of serum CDH6 and CDH11 levels have a high predictive value for adverse pregnancy outcomes in patients with EOSP.
