Diagnostic value of the systemic immune inflammation index and the systemic inflammation response index to rheumatoid arthritis
10.3969/j.issn.1673-4130.2024.20.018
- VernacularTitle:全身免疫炎症指数和全身炎症反应指数对类风湿关节炎的诊断价值
- Author:
Weiqiang LI
1
;
Xiang WANG
;
Jingjing DAI
Author Information
1. 南京医科大学附属淮安第一医院检验科,江苏淮安 223000
- Keywords:
systemic immune inflammation index;
systemic inflammation response index;
rheumatoid arthritis
- From:
International Journal of Laboratory Medicine
2024;45(20):2520-2523
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the diagnostic value of systemic immune inflammation index(SII)and systemic inflammation response index(SIRI)in rheumatoid arthritis(RA).Methods A total of 470 RA pa-tients diagnosed in the hospital from January to December 2023 were selected.According to the results of anti-cyclic citrullinated peptide(anti-CCP)antibody and rheumatoid factor(RF),RA was divided into four groups:anti-CCP antibody and RF negative group(52 cases),anti-CCP antibody positive RF negative group(70 cases),anti-CCP antibody negative RF positive group(18 cases),anti-CCP antibody and RF positive group(330 cases),and 300 healthy subjects were selected as control group.After calculating SII and SIRI in each group,Kruskal-Wallis was used to examine the difference between SII and SIRI in the anti-CCP antibody and RF negative group,anti-CCP antibody positive RF negative group,anti-CCP antibody negative RF positive group,anti-CCP antibody and RF positive group of RA patients and the control group,and the receiver operat-ing characteristic(ROC)curve was drawn to evaluate the diagnostic efficacy of SII and SIRI in the anti-CCP antibody and RF negative group,anti-CCP antibody positive RF negative group,anti-CCP antibody negative RF positive group,anti-CCP antibody and RF positive group of RA patients.Results SII and SIRI in four groups of RA patients were significantly higher than those in control group(P＜0.05).The area under the curve(AUC)of SII in evaluating the four groups of RA patients were 0.689,0.724,0.709,and 0.774,respec-tively.SIRI had an AUC of 0.679,0.729,0.679,and 0.772 in the evaluation of the four groups of RA pa-tients,respectively.Conclusion SII and SIRI are both elevated in patients with RA,and have certain predictive value for RA.
