Study on the application of thrombologram combined with coagulation and inflammation indexes in patients with threatened abortion
10.3969/j.issn.1673-4130.2024.20.013
- VernacularTitle:血栓弹力图联合凝血及炎症指标在先兆流产患者中的应用研究
- Author:
Yiqi SHEN
1
;
Jia WANG
;
Yu CAO
Author Information
1. 苏州大学附属常熟医院产科,江苏常熟 215500
- Keywords:
thrombologram;
coagulation function index;
peripheral blood inflammation index;
threatened abortion;
diagnostic value
- From:
International Journal of Laboratory Medicine
2024;45(20):2496-2500
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of Thromboelastogram(TEG)combined with conventional coagulation indexes and peripheral blood inflammation indexes in the diagnosis of threatened abortion.Methods A total of 33 patients with threatened abortion who were treated in the hospital from July 1,2022 to July 1,2023 were selected as the study group,and 40 healthy pregnant women in the first and second trimester of pregnan-cy were randomly selected as the control group.The blood routine,C-reactive protein(CRP),routine coagula-tion indexes and TEG were detected in the two groups,and the diagnostic value of TEG,routine coagulation indexes and peripheral blood inflammatory indexes in threatened abortion was analyzed.Results D-dimer(DD),white blood cell count(WBC),neutrophil count(NEU),neutrophil to lymphocyte ratio(NLR),CRP,coagulation Angle(α),maximum amplitude(MA),coagulation comprehensive index(CI)in the study group were higher than those in the control group(P＜0.05).The coagulation reaction time(R)and blood clot for-mation time(K)in the observation group were lower than those in the control group(P＜0.05).The correla-tion analysis between TEG and conventional coagulation indexes and inflammatory indexes showed that R was positively correlated with prothrombin time(PT)and activated partial thromboplastin time(APTT)(P＜0.05),K was negatively correlated with fibrinogen(FIB)(P＜0.05),and α was positively correlated with FIB(P＜0.05).MA and CI were positively correlated with PLT and FIB(P＜0.05).R and K were negatively cor-related with WBC,NEU and NLR(P＜0.05),α was positively correlated with CRP,WBC,NEU and NLR(P＜0.05),MA and CI were positively correlated with WBC,NEU and NLR(P＜0.05).Receiver operating characteristic curve analysis showed that the area under the curve of DD,CRP,α and the combination of the three were 0.775,0.748,0.922 and 0.959,respectively(P＜0.001).Conclusion TEG can be used to evaluate the coagulation function of patients with threatened abortion,and its combination with conventional coagula-tion indexes and peripheral blood inflammation indexes can provide an important basis for clinical diagnosis of threatened abortion,and has certain guiding significance for clinical diagnosis and treatment.
