Effect of different administration routes of snake venom hemagglutinin combined with HFOV on neonatal pulmonary hemorrhage
10.3969/j.issn.1673-4130.2024.18.007
- VernacularTitle:蛇毒血凝酶不同给药途径联合HFOV治疗新生儿肺出血的效果
- Author:
Mingyu LI
1
;
Mei YANG
Author Information
1. 眉山市妇幼保健院新生儿科,四川眉山 620020
- Keywords:
snake venom hemagglutinin;
high frequency oscillation ventilation;
neonatal pulmonary hemorrhage;
glucose-6-phosphate dehydrogenase;
type Ⅱ alveolar cell surface antigen
- From:
International Journal of Laboratory Medicine
2024;45(18):2213-2217,2222
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of different ways of giving snake venom hemagglutination en-zyme combined with high frequency oscillatory ventilation(HFOV)on neonatal pulmonary hemorrhage(NPH)and its influence on coagulation function,glucose-6-phosphate dehydrogenase(G6PD)and type Ⅱalveolar cell surface antigen(KL-6).Methods A total of 102 NPH from January 2021 to June 2023 were se-lected and divided into the study group and the control group,51 cases in each group.Both groups were given HFOV treatment,on this basis,the control group was given snake venom hemthrombin by intravenous injec-tion,and the study group was given snake venom hemthrombin by intravenous injection combined with intra-tracheal drip.The treatment effect,pulmonary hemorrhage stop time,mechanical ventilation time,hospital stay of the two groups were compared,as well as arterial partial oxygen pressure(PaO2),activated partial thromboplastin time(APTT),PaO2 to inhaled oxygen concentration ratio(PaO2/FiO2),D-dimer(D-D),arte-rial partial carbon dioxide pressure(PaCO2),prothrombin time(PT),pH value,fibrinogen degradation prod-ucts(FDP),serum G6PD,KL-6 levels and complication rate before and after treatment.Results The total ef-fective rate of the study group was[94.12％(48/51)]higher than that of the control group[80.39％(41/51)],and the difference was statistically significant(P＜0.05).The pulmonary hemorrhage stopping time,hospital stay time and mechanical ventilation time in the study group were shorter than those in the control group(P＜0.05).Moreover,at 24 h and 72 h after treatment,PaO2/FiO2,PaO2 and pH values of the study group were higher than those of the control group,and PaCO2 was lower than those of the control group,and the differences were statistically significant(P＜0.05).At 24 h and 72 h after treatment,the D-D,KL-6,FDP,APTT and PT of the study group were lower than those of the control group,and G6PD was higher than that of the control group,and the differences were statistically significant(P＜0.05).The complication rate of the study group[5.88％(3/51)]was lower than that of the control group[19.61％(11/51)],and the differ-ence was statistically significant(P＜0.05).Conclusion The combination of intravenous injection of snake venom hemagglutinase and intratracheal infusion in NPH can regulate the blood coagulation function,serum KL-6 and G6PD levels in children,improve blood oxygen index,reduce the risk of complications,and promote disease recovery,and the clinical application effect is good.
