Research progress on the role of IL-22 in intestinal barrier maintenance and related diseases
10.3969/j.issn.1673-4130.2024.15.018
- VernacularTitle:IL-22在肠道屏障维护及相关疾病中的作用机制研究进展
- Author:
Liping WANG
1
;
Xiuyu XU
Author Information
1. 重庆医科大学附属第一医院检验科,重庆 400016
- Keywords:
interleukin-22;
gut microbiota;
leaky gut;
intestinal barrier
- From:
International Journal of Laboratory Medicine
2024;45(15):1891-1896,1920
- CountryChina
- Language:Chinese
-
Abstract:
The intestinal barrier is a complex system that plays a crucial role in maintaining physiological balance and resisting the invasion of exogenous pathogens.In recent years,a large amount of research has fo-cused on the role of cytokines in maintaining intestinal barrier homeostasis,especially interleukin(IL)-22,which has received widespread attention.1L-22 is mainly secreted by immune cells such as Th17 cells,γδ T cells,and innate lymphoid cells,and is central in promoting the proliferation of intestinal epithelial cells,main-taining their integrity,and regulating mucosal antimicrobial defense.Dysfunction of the intestinal barrier is closely related to the development of leaky gut-related diseases,such as inflammatory bowel disease,irritable bowel syndrome,alcoholic liver disease,and so on.These diseases usually involve an increase in intestinal per-meability,allowing harmful substances to enter the bloodstream through the intestinal epithelium and affect multiple organs and systems,especially the digestive system.Notably,the interaction of IL-22 with the gut mi-crobiota has become a current research hotspot.This article aims to review the recent research progress on the role of IL-22 in intestinal barrier function and explore the mechanisms of IL-22 in regulating leaky gut-related digestive system diseases.
