Research progress on the role of neutrophil elastase and its inhibitor in sepsis related ARDS
10.3969/j.issn.1673-4130.2024.14.019
- VernacularTitle:中性粒细胞弹性蛋白酶及其抑制剂在脓毒症相关ARDS中作用的研究进展
- Author:
Yushuang LI
1
;
Jixian TIAN
Author Information
1. 湖南师范大学附属张家界医院,湖南张家界 427000
- Keywords:
sepsis;
acute respiratory distress syndrome;
neutrophil elastase;
sivelestat sodium
- From:
International Journal of Laboratory Medicine
2024;45(14):1761-1766
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis related acute respiratory distress syndrome(ARDS)is one of the serious complications of sepsis,with high morbidity and mortality.Neutrophil elastase(NE)plays an important role in its pathophysi-ological processes,involving in many processes such as alveolar-capillary barrier breakdown,oxidative stress and inflammatory response,autophagy,cell death and so on.Sivelestat sodium,as the only marketed specific NE inhibitor(NEI),shows great potential in reducing inflammatory responses and protecting lung tissue.This article mainly reviews the mechanism of NE and NEI in sepsis related ARDS,and briefly discusses the poten-tial treatment of sepsis related ARDS and sivelestat sodium,in order to provide reference for clinical treat-ment.
