Evaluation value of serum levels of AQP4,DCN,Apelin in the diagnosis and pathological staging of retinopathy of prematurity
10.3969/j.issn.1673-4130.2024.14.015
- VernacularTitle:血清AQP4、DCN、Apelin水平对早产儿视网膜病变诊断及病理分期的评估价值
- Author:
Kun LI
1
;
Yanping WU
;
Junli FENG
Author Information
1. 沧州市中心医院小儿眼科,河北沧州 061000
- Keywords:
aquaporin 4;
decorin;
Apelin;
retinopathy of prematurity;
diagnosis;
pathological staging
- From:
International Journal of Laboratory Medicine
2024;45(14):1740-1744
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the evaluation value of serum levels of aquaporin 4(AQP4),decorin(DCN),and Apelin in the diagnosis and pathological staging of retinopathy of prematurity(ROP).Methods A total of 64 ROP children(128 eyes)who received treatment in the hospital from October 2021 to October 2022 were collected as the ROP group,while 64 premature infants of the same birth age without ROP((128 eyes)were regarded as the normal group.Enzyme linked immunosorbent assay(ELISA)was applied to meas-ure the levels of serum AQP4,DCN,and Apelin.Multivariate Logistic regression was applied to analyze the factors that affected the occurrence of ROP.Receiver operating characteristic(ROC)curve was applied to ana-lyze the diagnostic value of serum AQP4,DCN,and Apelin in the occurrence and pathological staging of ROP.Results Compared with the normal group,the birth weight in the ROP group was obviously reduced(P＞0.05).The serum levels of AQP4,DCN,and Apelin in the ROP group were obviously higher than those in the normal group(P＜0.05).The serum levels of AQP4,DCN,and Apelin in children with ROP at different pathological stages showed statistically significant differences(P＜0.05).According to multivariate Logistic regression analysis,AQP4,DCN,and Apelin were risk factors affecting the occurrence of ROP(P＜0.05),while birth weight was a protective factor affecting the occurrence of ROP(P＜0.05).The combination of se-rum AQP4,DCN,and Apelin had the largest area under the curve(AUC)for the diagnosis of ROP,which was superior to the individual diagnosis of serum AQP4,DCN,and Apelin(Zcombination-AQP4=3.018,P=0.003,Zcombination-DCN=2.306,P=0.021,Zcombination-Apelin=3.301,P=0.001).The combination of serum AQP4,DCN,and Apelin had the largest AUC for the diagnosis of pathological staging of ROP,which was superior to the indi-vidual diagnosis of serum AQP4,DCN,and Apelin(ZcombinationAQP4=2.735,P=0.006,Zcombination-DCN=2.228,P=0.026,Zcombination-Apelm=2.594,P=0.001).Conclusion The serum levels of AQP4,DCN,and Apelin in children with ROP are obviously increased,and the combination of the three could better diagnose the occurrence of ROP and evaluate the pathological staging.
