Diagnostic efficacy of serum PⅢNP combined with NT-proBNP in patients with H type hypertension complicated with heart failure
10.3969/j.issn.1673-4130.2024.13.010
- VernacularTitle:血清PⅢNP、NT-proBNP联合检测对H型高血压患者合并心力衰竭的诊断效能分析
- Author:
Yue SUN
1
;
Guojing YANG
;
Na CHENG
Author Information
1. 中国航天科工集团七三一医院检验科,北京 100074
- Keywords:
type Ⅲ procollagen amino terminal peptide;
N-terminal pro-B-type natriuretic peptide;
H-type hypertension;
heart failure
- From:
International Journal of Laboratory Medicine
2024;45(13):1586-1590
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic efficacy of serum type Ⅲ procollagen amino terminal pep-tide(PⅢNP)combined with N-terminal pro-B-type natriuretic peptide(NT-proBNP)in patients with H type hypertension complicated with heart failure.Methods A total of 102 patients with H-type hypertension com-bined with heart failure who received treatment in the hospital from October 2020 to October 2023 were se-lected as the study group,and 87 patients with simple H-type hypertension admitted during the same period were selected as the control group.After admission,the levels of serum PⅢNP and NT-proBNP were detected and compared among all groups.Receiver operating characteristic(ROC)curve was used to evaluate the diag-nostic efficacy of serum PⅢNP and NT-proBNP in patients with H-type hypertension complicated with heart failure.The risk factors affecting H-type hypertension complicated with heart failure were explored by multi-variate Logistic regression analysis.Results The serum levels of PⅢNP and NT-proBNP in the study group were higher than those in control group(P<0.05).The serum levels of PⅢNP and NT-proBNP in grade ⅣH-type hypertension patients with heart failure were significantly higher than those in grade Ⅲ,grade Ⅱ and control group(grade Ⅳ>grade Ⅲ>grade Ⅱ>control individuals,P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum PⅢNP in diagnosing H-type hypertension complicated with heart failure was 0.855(95%CI:0.805-0.905),and the AUC of serum NT-proBNP in diagnosing H-type hypertension complicated with heart failure was 0.830(95%CI:0.780-0.880),the AUC of the combined de-tection in diagnosing H-type hypertension complicated with heart failure was 0.912(95%CI:0.862-0.962).Serum PⅢNP(OR=3.931,95%CI:1.919-8.056),NT-proBNP(OR=3.622,95%CI:2.060-6.369),hy-persensitivity C-reactive protein(OR=2.776,95%CI:1.786-4.315)and smoking(OR=3.387,95%CI:2.051-5.594)were risk factors for H type hypertension complicated with heart failure(P<0.05).Conclu-sion Serum levels of PⅢNP and NT-proBNP are increased in patients with H type hypertension complicated with heart failure,and the levels of both are closely related to cardiac function grade.Clinical detection could be used to judge the development of patients'disease,and the combination of the two has better clinical diag-nostic efficacy for H type hypertension complicated with heart failure.
