Study on TGF-β1,CTGF and VEGF expression in decidual tissue of pregnant patients with uterine scar pregnancy after cesarean section
10.3969/j.issn.1673-4130.2024.10.010
- VernacularTitle:剖宫产术后子宫瘢痕妊娠患者蜕膜组织中TGF-β1、CTGF和VEGF表达的研究
- Author:
Xiaoling ZHONG
1
;
Lin YANG
;
Mei XU
Author Information
1. 贵州医科大学临床医学院,贵州贵阳 550000
- Keywords:
uterine scar pregnancy after cesarean section;
decidual tissue;
transforming growth factorβ1;
connective tissue growth factor;
vascular endothelial growth factor
- From:
International Journal of Laboratory Medicine
2024;45(10):1198-1202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the pathogenesis of cesarean scar pregnancy(CSP)by detecting the ex-pression of transforming growth factor β1(TGF-β1),vascular endothelial growth factor(VEGF),and connec-tive tissue growth factor(CTGF)the decidua tissue of cesarean scar and the decidual tissue of uterine cavity of CSP,and the decidua tissue of cesarean scar and the decidual tissue of uterine cavity of normal pregnancy after cesarean section.Methods Decidual tissues of totally 120 cases of CSP group and 120 cases of normal preg-nancy group after induced abortion at the Department of Obstetrics and Gynecology in Guizhou Medical Uni-versity Affiliated Hospital were collected.The expression of TGF-β1,CTGF,and TGF and VEGF in decidual tissue was detected using immunohistochemistry.Results The expression of TGF-β1 and CTGF in the decid-ual tissue of cesarean scar in the CSP group was higher than that in the decidual tissue of uterine cavity in the CSP group and the decidua tissue of cesarean scar in the normal pregnancy group,and the differences were sta-tistically significant(P＜0.05).The expression of VEGF the decidua tissue of cesarean scar in the CSP group was not significantly different from that in the decidual tissue of uterine cavity in the CSP group and the decid-ua tissue of cesarean scar in the normal pregnancy group(P＞0.05).TGF-β1 in the decidual tissue was posi-tively correlated with CTGF(r=0.910,P＜0.05),and TGF-β1 and VEGF had no correlation(r=-0.032,P＞0.05).Conclusion The high expression of TGF-β1 and CTGF in decidual tissue of cesarean scar of CSP may be a high risk factor for CSP,and measures should be taken to inhibit the production of TGF-β1 and CT-GF in cesarean scar,so as to open up a new way to prevent the occurrence of CSP.
