Predictive value of serum sTREM-1 and HBP on postoperative infection in cases with oral and maxillofacial tumors complicated with diabetes mellitus
10.3969/j.issn.1673-4130.2024.10.006
- VernacularTitle:血清sTREM-1、HBP对口腔颌面肿瘤合并糖尿病患者术后感染的预测价值
- Author:
Makexi HAILIDA
1
;
Musha AIKEREMU
;
Fang YANG
Author Information
1. 新疆医科大学附属肿瘤医院(新疆肿瘤医院)门诊部,新疆乌鲁木齐 830011
- Keywords:
oral and maxillofacial tumors;
diabetes mellitus;
soluble myeloid cell trigger receptor-1;
heparin-binding protein
- From:
International Journal of Laboratory Medicine
2024;45(10):1180-1183
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of serum soluble myeloid cell trigger receptor-1(sTREM-1)and heparin-binding protein(HBP)on postoperative infection in cases with oral and maxillofacial tumors complicated with diabetes mellitus.Methods A total of 110 patients with oral and maxillofacial tumors complicated with diabetes mellitus treated in the hospital from January 2020 to December 2022 were selected as the study objects,and the patients were divided into uninfected group(n=83)and infected group(n=27)according to the occurrence of postoperative infection.Serum sTREM-1 and HBP levels in patients with oral and maxillofacial tumors diabetes mellitus before surgery were detected by enzyme-linked immu-nosorbent assay.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum sTREM-1 and HBP on postoperative infection in patients.The related factors of postoperative infection were investigated by multivariate Logistic regression.Results The levels of sTREM-1 and HBP in the infec-ted group were higher compared with the uninfected group,and the differences were statistically significant(P＜0.05).The area under the curve(AUC)of serum sTREM-1 and HBP levels in predicting postoperative infection was 0.707(95％CI:0.661-0.756)and 0.885(95％CI:0.838-0.931),respectively,and the AUC of the combined prediction was 0.931(95％CI:0.889-0.975).The number of patients with hypertension,in-traoperative blood loss,operation time and hospital stay in infected group was higher compared with in non-in-fected group,and the number of advanced nursing was lower compared with the uninfected group,and the differences were statistically significant(P＜0.05).Multivariate Logistic regression results showed that the length of hospitalization≥14 d(OR=2.401,95％CI:1.331-4.332),sTREM-1＞50.49 pg/mL(OR=3.494,95％CI:1.601-7.662),HBP＞159.84 ng/L(OR=4.473,95％CI:1.819-10.997)were the influential fac-tors for postoperative infection(P＜0.05).Conclusion Preoperative serum sTREM-1 and HBP levels are sig-nificantly increased in patients with oral and maxillofacial tumor complicated with diabetes mellitus who also have postoperative infection,and the increase of serum sTREM-1 and HBP levels are influential factor for postoperative infection,and the two levels have certain clinical value in assisting the evaluation of postopera-tive infection.
